gernert
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![[*]](images/xp/default_icon.gif) posted on 7-16-2010 at 07:35 PM |
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Bioinformatics and Systems Biology Research Scientist
Bioinformatics and Systems Biology
Research Scientists, Analysts, Post Docs
Positions in Bioinformatics/ Systems Biology with a focus on Microarray Analysis are available in the laboratory of Dr. Bali Pulendran at the Emory
Vaccine Center in Atlanta, USA. The successful applicant will join a dynamic, interdisciplinary group of researchers including immunologists,
vaccinologists, clinicians, bioengineers and bioinformaticians.
RESPONSIBILITIES:
The successful applicant will work in a multi-disciplinary team to use microarray and systems biology approaches to explore the induction and
regulation of immune responses in humans, non human primates and mice to pathogens, vaccines, and adjuvants. The primary goals of this effort are to:
(i) identify key, early correlates of vaccination or ‘signatures’ that defines the initial parameters for later development of protective immune
responses, using several vaccines (e.g. Nature Immunology vol 10, 1, p116-125, 2009); (ii) identify early signatures of disease progression in
infectious diseases, and (iii) exploit the knowledge gained from (i) and (ii) in the design of novel adjuvants and vaccines.
The responsibilities of this position includes:
• development of analysis protocols for large in-house and public gene-expression datasets (currently greater than 1000 in-house microarray files),
• development or adaptation of software tools and scripts to meet the needs of the projects,
• leading the analysis, or managing the analysts through developed protocols,
• integration of micoarray data with protein interaction network information and/or with additional immunological data,
• be a team leader. confident to collaborate with a multi-disciplanary team and to manage a bioinformatics research group. Coordination with
statisticians,
• maintaining a database / archive for the curation and accessibility of the raw files, normalized files and meta-analyses, collaborative “sharing” of
experimental data and results.
REQUIREMENTS:
The qualified applicant will have a Masters Degree or a Ph.D. in bioinformatics, a relevant biological discipline, or in computer science plus
demonstrated experience in bioinformatics research. Previous demonstrated experience (2-5years) with large-scale Microarray Analyses required.
Previous experience with genomic analyses, particularly network analysis would be strongly desirable. Solid understanding of fundamental systems
biology concepts. A clear understanding of the latest developments in gene expression and microarray technologies and the challenges
<b>bottom</b>ociated with “microarray analysis” and meta-analyses.
Familiarity with working in a Linux/Unix environment, plus experience with relational databases (e.g. MySQL, Oracle) and fluency in at least one
programming language (Perl, Java, Python, C or C++) are required.
Proven experience in leading a scientific research group.
PREFERENCES:
Research-oriented curiosity to seek out and develop novel tools, and create a “new way of looking at things”. In-depth knowledge of online / open
source bioinformatics tools, databases, and pathway analysis. Wide-understanding of commercially available bioinformatics tools. Strong quantitative
or statistical background would be a plus.
Excellent attention to detail and analytical skills. Excellent organizational skills. Ability to work independently.
Applicant must have the ability to work in a fast moving interdisciplinary team environment, as well as the ability to discuss issues and provide
solutions to scientists with different backgrounds. Excellence in verbal and written communication skills.
HOW TO APPLY: Please send CV to Bali Pulendran at: bpulend@emory.edu
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