ymding
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Registered: 6-20-2002
Location: New York
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 posted on 6-22-2002 at 05:27 AM |
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Experienced Bioinformatics Postdoctoral Fellow Seeking Job
Yueming Ding
Room C-670, Bioinformatics Center
Wadsworth Center for Laboratories and Research
New York State Department of Health
P.O.Box 509, Albany, NY 12201
TEL: 518-473-8429 FAX: 518-473-2900
ymding@wadsworth.org
SUMMARY OF QUALIFICATIONS
· Ph.D. in Genetics and 2 years postdoctoral training in bioinformatics
· Extensive experience in both molecular genetics and bioinformatics
· Expertise in sequence analysis with statistical and computational methods
· Strong teamwork skills
EDUCATION
Ph.D. in Genetics, University of Iowa, Iowa City, IA, July, 2000
M.S. in Cell Biology, Nanjing Normal University, Nanjing, China, July, 1988
B.S. in Biology, Nanjing Normal University, Nanjing, China, July, 1985
Additional Coursework:
University of Iowa, State University of New York at Albany, Renssleaer Polytechnic Institute, 1999-present
· Computational Molecular Genetics
· Programming in Perl
· Programming in C
· Database Management Systems
· Data Structures
· Discrete Probability
· Statistics and Continuous Probability
PROFESSIONAL EXPERIENCE
1. Research Affiliate (Post-Doctoral), Bioinformatics Center, Wadsworth Center for Laboratories and Research, New York State Dept. of Health, Albany,
NY, 2000-present
Mentor: Charles (Chip) E. Lawrence, Ph.D.
· Computational identification and characterization of the transcriptional
regulatory elements that regulate gene expression and the transcription
factors that specifically bind to these cognate sites in hox gene
clusters by statistical and comparative genome analysis
2. Graduate bottomistant, University of Iowa, Iowa City, IA, 1994-2000
Advisor: Curt D. Sigmund, Ph.D.
Research:
· Developed a novel transgenic model in which hypertension was caused by the selective activation of an intra-renal renin-angiotensin system by tissue
specific targeting
· Analyzed the transcription regulation of angiotensinogen gene
Teaching:
· Health Sciences Microbiology
· Biochemistry and Molecular Biology
3. Instructor, Nanjing Normal University, Nanjing, China, 1988-1994
Research:
· Established pig-mouse somatic cell hybrids for pig gene mapping
· Purified phytohemagglutinin and analyzed its properties
· Studied the conservation and other properties of kinetochore proteins by using human autoantibodies from autoimmune diseases
Teaching:
· Cell Biology for seniors
AWARDS AND HONORS
1. Best Abstract Award ($800 for travel) in 2000 Research Day held by the Department of Internal Medicine, the University of Iowa College of Medicine,
2000
2. Predoctoral Fellowship, American Heart bottomociation, Iowa Affiliate. Title: "Examination of the Intra-Renal Renin-Angiotensin System in
Transgenic Mice". Total award: $28,200 for 2 years, 1997-1999
COMPUTER, STATISTICS AND BIOINFORMATICS SKILLS
· Perl/CGI
· C/C++
· HTML
· SQL
· BLAST
· Unix/Windows/Mac
· Gibbs Motif Sampler
· Bayes Block Aligner
· Dscan
· PipMaker
BIOMEDICAL SKILLS
· RNA and DNA Isolation
· PCR and immunohistochemistry
· Northern and Southern Blotting
· RNase Protection bottomay
· Primer Extension
· In Situ Hybridization
· DNA Cloning and Sequencing
· Design and Generation of Transgene and Knockout Constructs
· Chronic Implantation of Catheters for the Recording of Blood Pressure.
· Cell Culture
PUBLICATIONS
1. Y Ding and CE Lawrence. Computational Identification and Analysis of Transcriptional Regulatory
Elements in Hox Genes. In preparation.
2. Ding Y, Stec DE and CD Sigmund. Genetic Evidence That Lethality in Angiotensinogen-Deficient Mice Is
Due to Loss of Systemic but Not Renal Angiotensinogen. J. Biol. Chem. 276:7431-7436, 2001
3. Ding Y and CD Sigmund. Androgen-Dependent Regulation of Human Angiotensinogen Expression in KAP-hAGT
Transgenic Mice. Am. J. Physiol. 280:F54-F60, 2001
4. Davisson RL, Y Ding, DE Stec, JF Catterall and CD Sigmund. Novel Mechanism of Hypertension Revealed by
Cell-specific Targeting of Human Angiotensinogen in Transgenic Mice. Physiological Genomics 1(1):3-9,
1999
5. Ding Y, RL Davisson, DO Hardy, LJ Zhu, DC Merrill, JF Catterall and CD Sigmund. The Kidney Androgen-
regulated Protein (KAP) Promoter Confers Renal Proximal Tubule Cell-specific and Highly Androgen-
responsive Expression on the Human Angiotensinogen Gene in Transgenic Mice. J. Biol. Chem. 272(44):
28142-28148, 1997
6. Ding Y, Y Chen and H Zhu. Progress in Pig Gene Mapping. Progress in Bioengineering 14(5):12-16, 1994
7. Zhang X, Y Ding, Y Chen, B Ding and M Dai. Lymphocyte Transformation Activity of PHA-p from A Jiangsu
Cultivar of Phaseolus Vulgaris. J Nanjing Normal Univ. 14(3):71-74, 1991
8. Ding B, M Dai, J Yu, X Zhang, Y Ding and Y Chen. Purification and Properties of Phytohemagglutinin
Isolectins from Jiangsu Phaseolus Vulgaris. Chinese Biochemical Journal 7(1):25-30, 1991
9. Ding Y, F You, Y Wang and Y Chen. The Studies on Conservation and Nature of Kinetochore Antigens with
Human Autoantibodies from Scleroderma Patients. Zoological Research 11(3):215-221, 1990
10. Ding Y and Y Chen. Genetics and the Future of Medicine. World Science 8:22-24, 1988
11. Hua J, X Huang, Y Ding, K Du, F You and M Le. Color Composing and Density Grading Technique for
Electron Micrograph of Human Cancer Cells. J. Nanjing Normal Univ. 11(1):51-53, 1988
ABSTRACTS
1. Ding Y and CD Sigmund. Genetic Evidence That Loss of Intra-Renal Angiotensinogen Is Not the Cause of
Lethality in Angiotensinogen-Deficient Mice. Hypertension 36(4):687, 2000
2. Ding Y and CD Sigmund. Androgen Dependent Expression of the Kidney Androgen Regulated Protein (KAP)
Promoter in Renal Proximal Tubule Cells of Transgenic Mice. J. Am. Soci. Nephrology 10(9):403A, 1999
3. Ding Y and CD Sigmund. Temporal Control of Human Angiotensinogen Expression Driven by the Kidney
Androgen-regulated Protein Promoter in Transgenic Mice. FASEB J. 13(4):A381, 1999
4. Davisson RL, Ding Y, JF Catterall and CD Sigmund. Inducible Hypertension Due to the Selective
Activation of an Intra-renal Renin-angiotensin System in Transgenic Mice. J. of Hypertension
16(Suppl. 2):S7, 1998
5. Sigmund CD, Y Ding, DO Hardy, LJ Zhu, JF Catterall and RL Davisson. Selective Activation of an
Intrinsic Intrarenal Renin-angiotensin System Results in Hypertension via a Renal Ang-II-dependent but
Plasma Ang-II-independent Mechanism in Transgenic Mice. J. Am. Soci. Nephrology 8(9):308A, 1997
6. Ding Y, RL Davisson, DO Hardy, LJ Zhu, DC Merrill, JF Catterall and CD Sigmund. Inducible Hypertension
Due to the Selective Activation of an Intrinsic Intra-renal Renin-angiotensin System in Transgenic Mice.
Hypertension 30(3):480, 1997
7. Ding Y, RL Davisson, DO Hardy, LJ Zhu, JF Catterall and CD Sigmund. Inducible Hypertension in
Transgenic Mice Containing the Human Angiotensinogen Gene Under the Control of the Kidney
Androgen-regulated Protein Promoter. Am. J. Hypertension 10(4):32A, 1997
8. Ding Y, RL Davisson, DO Hardy, LJ Zhu, JF Catterall and CD Sigmund. Inducible Hypertension in
Transgenic Mice Containing the Human Angiotensinogen Gene Under the Control of the Kidney
Androgen-regulated Protein Promoter. FASEB J. 11(3):A243, 1997
9. Davisson RL, Y Ding, HS Kim, JH Krege, DO Hardy, JF Catterall, O Smithies and CD Sigmund. Development
of Transgenic Animal Models for Studying the Renin-angiotensin System in Hypertension, Renal Function
and Renal Development. J. Investigative Medicine 44(3):321A, 1996
10. Ding Y, RL Davisson, DO Hardy, NL Sinclair, L Robbins, JF Catterall and CD Sigmund. Kidney-specific
Expression of the Human Angiotensinogen Gene under the Control of the Kidney Androgen-regulated
Promoter in Transgenic Mice. FASEB J. 10(3):A21, 1996
PRESENTATIONS
1. Council for High Blood Pressure Research, Washington, D.C., September 2000
2. Council for High Blood Pressure Research, Washington, D.C., September 1997
3. Iowa Academy of Science, Dubuque, IA, April 1997
4. Experimental Biology '97, New Orleans, LA, April 1997
5. Experimental Biology '96, Washington, D.C., April 1996
REFERENCES:
Available upon request.
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